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3rd International Symposium on Pharmaceutical Engineering Research - SPhERe
25 - 27 September 2019
Preliminary Programme
Version: 2019-07-26

WEDNESDAY, 25 SEPTEMBER 2019

11:00 Registration
13:00 Opening
Opening and Welcome Prof. Dr.-Ing. Stephan Scholl, Conference Chair
Welcome Björn Thümler, Minister for Science & Culture of the German State of Lower Saxony
Welcome Prof. Dr.-Ing. Anke Kaysser-Pyzalla, President of TU Braunschweig
SESSION I: Microsystems for Analytics, Screening & Continuous Processing
13:45 KEYNOTE LECTURE Emulation of Gut-Liver Crosstalk: An Organ-on-Chip Platform for Translational Research and Drug Development.
A. Mosig, University Hospital Jena
14:20 Fish in Chip: A Microfluidic Platform for Light Sheet Microscopy of Zebrafish Larvae.
K. Mattern1,3,4, J. W. von Trotha2, R. W. Köster2, A. Dietzel1,3
1Institut für Mikrotechnik, TU Braunschweig; 2Institut für Zoologie, TU Braunschweig; 3Zentrum für Pharmaverfahrenstechnik (PVZ), TU Braunschweig; 4minds GmbH i.G., Braunschweig.
14:40 Developing Near-Infrared Fluorescent Carbon Nanotube Constructs for Biosensing and Bioimaging Applications.
M. M. Safaee, M. Gravely, D. Roxbury, University of Rhode Island
15:00 Parallel Multi-Parametric Monitoring of Single Pancreatic Islets in a Microfluidic Organ-on-Chip System Made from Glass.
T. Schulze 1,3,4, K. Mattern2,3, A. Dietzel2,3, I. Rustenbeck1,3,4
1Institute of Pharmacology and Toxicology, 2Institute of Microtechnology, 3PVZ-Center of Pharmaceutical Engineering, 4QUANOMET - Quantum and Nanometrology at the TU Braunschweig
15:20 Scaffold-based Lung Tumor Cultures on Porous Microparticle Substrates.
D. Dhamecha, D. Le, R. Movsas, J. U. Menon, University of Rhode Island
15:40 COFFEE BREAK
POSTER SESSION
16:15 For posters, a 3 min introductory presentation is schedulded, followed by a dedicated poster session.
18:15 Guided PVZ Tours
19:15 GET TOGETHER

THURSDAY, 26 SEPTEMBER 2019

SESSION II: Production Processes for Chemical API
08:30 INVITED LECTURE Shaping the Process to Fit the Assets: The Lonza Way.
A. Klein, Lonza AG, Visp
08:55 Solvation Free Energy Predictions from Molecular Dynamics Simulations by Improved Alchemical Pathways and Optimized Force Field Parameters.
A. Mecklenfeld1,2, G. Raabe1
1 Institut für Thermodynamik, TU Braunschweig;, 2 Center of Pharmaceutical Engineering, TU Braunschweig
09:15 Fluid Dynamic Characterization of the Novel ASKR Crystallizer / Reactor.
A. Wilk, Wilk-Graphite, Lörrach
09:35 Continuous Krapcho Dealkoxycarbonylation in API Synthesis.
M. C. Rehbein1,2, S. Husmann1, J. Wolters1, L. Priess1, C. Lechner3, C. Kunick2,3, S. Scholl1,2
1TU Braunschweig, Institute for Chemical and Thermal Process Engineering; 2TU Braunschweig, Center for Pharmaceutical Engineering; 3TU Braunschweig, Institute for Medicinal and Pharmaceutical Chemistry
09:55 Ligands for M-NHC synthesis: Continuous Flow Di-N-Alkylation of 1H-Benzimidazole in a Fixed Bed Reactor.
T. Sauk1,2, C. Heiduk1,2, L. Henke1,2, C. Xiao1,2, S. Scholl1,2
1TU Braunschweig, Institute for Chemical and Thermal Process Engineering; 2TU Braunschweig, Center for Pharmaceutical Engineering
10:15 COFFEE BREAK
SESSION III: Production Processes for Biological API
10:45 INVITED LECTURE CO2 Extraction - a Production Process for the Recovery of API.
D. Gerard, Flavex GmbH, Rehlingen
11:10 Engineering Yeast Toward Production of Bioactive Polycyclic Polyprenylated Acylphloroglucinols.
B. Liu1, 2, L. F. Kalz1, Y. Jia1, M. Grull1, 2, T. Beuerle1, 2, L. Beerhues1, 2
1 Institute of Pharmaceutical Biology, TU Braunschweig; 2Center of Pharmaceutical Engineering (PVZ), TU Braunschweig
11:30 Efficient Coupling of Extraction and Partial Synthesis for the Production of the Antimalarial Artemisinin
S. Triemer1, K. Gilmore2, A. Seidel-Morgenstern1,3
1 Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg; 2 Max Planck Institute of Colloids and Interfaces, Potsdam; 3 Otto von Guericke University, Magdeburg
11:50 A Tool Box for Transgene Expression in CHO Cell Lines.
M. Heine, L. Rabsch, H. Ziehr
Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Division: Pharmaceutical Biotechnology, Braunschweig
12:10 LUNCH
HOT TOPIC SESSION
CANNABIS FOR MEDICINAL USE - PRODUCTION CHALLENGES AND LEGAL REQUIREMENTS
13:30Cannabis for Medical Use - Key Elements of Regulation
W. Knöss, Federal Institute for Drugs and Medical Devices, Bonn
14:15Cultivation and Production of Medicinal Cannabis - Global View
C. Zieres-Nauth, Medropharm Deutschland GmbH, Schwülper
14:45 COFFEE BREAK
SESSION IV: Formulation
15:00

KEYNOTE LECTURE Pellets 4.0 - Advanced Fluidized Bed Technologies.
A. Grave, Glatt GmbH, Binzen
15:35Manufacturing of Defined Porous Silica Aggregates for the Production of Individualized Medicines.
S. Melzig1,2, M. Kruppa1,2, S. Bahnmüler1,2, J. H. Finke1,2, C. Schilde1,2
1 Institute for Particle Technology, TU Braunschweig; 2 Center of Pharmaceutical Engineering - PVZ, TU Braunschweig
15:55Use of Inverse Gas Chromatography in Formulation Development of Solid Dosage Forms.
J. Patera, P. Zamostny, T. Skolakova, M. Slamova, E. Soldanova, University of Chemistry and Technology, Prague
16:15Development of an Orodispersible Pediatric Formulation for Poorly Water Soluble, Unpalatable Drugs.
K. Ibrahim1, Y. Deng 1,3, J. Shen1,2
1Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island; 2Department of Chemical Engineering, University of Rhode Island; 3School of Pharmacy, Fujian Medical University,Fuzhou
16:35Influence of Formulation Parameters During Drying of API Nanosuspensions in a Fluidized Bed Granulation Process.
M. Wewers1,2, J. H. Finke1,2, M. Juhnke3 & A. Kwade1,2
1 Institut für Partikeltechnik, TU Braunschweig; 2 PVZ, Centre of Pharmaceutical Engineering, TU Braunschweig; 3 Novartis Pharma AG, Basel
16:55 COFFEE BREAK
SESSION V: Pharmaceutical and Biological Processes
17:15 INVITED LECTURE Process Intensification in Viral Vaccine Manufacturing.
U. Reichl, MPI Magdeburg
17:40Particle Based Cultivation of Lentzea aerocolonigenes in Membrane Aerated Stirred Bioreactors for Increased Rebeccamycin Production.
K. Pommerehne1,2, J. Niebusch1, N. Wurzler1, R. Krull1,2
1Institute of Biochemical Engineering, TU Braunschweig; 2Center of Pharmaceutical Engineering, TU Braunschweig
18:00Accelerating Biomanufacturing by Modeling of Continuous Bioprocessing - Piloting Case Study of Monoclonal Antibody Manufacturing.
Prof. Dr.-Ing. J. Strube, Dr.-Ing. S. Zobel-Roos, TU Clausthal
18:20Developing A Glucose-Limited Galactose-Supplemented Fed-Batch Strategy.
M. Evert1, M. Heine1, A. Roß1, U. Rau2,
1Fraunhofer Institute for Toxicology and Experimental Medicine, ITEM; 2TU Braunschweig
18:40 End of Second Day
CONFERENCE DINNER
18:40 Conference Dinner
Venue of the Conference Dinner
Herzog Anton Ulrich Museum - Museumstraße 1 - 38100 Braunschweig

FRIDAY, 27 SEPTEMBER 2019

SESSION VI: Solid Preparations
08:30 KEYNOTE LECTURE Amorphous Drugs and Dosage Forms - New Developments and Perspectives.
T. Rades, University of Copenhagen
09:05DEM-PBM Simulation of Pharmaceutical Pellet Rounding in the Spheronization Process.
S. Antonyuk, TU Kaiserslautern
09:25Identification of Controling Steps of Drug Release Using Regression Modeling of Tablet Disintegration.
K. Dufkova; D. T. Tran; P. Zamostny, University of Chemistry and Technology, Prague
09:45Effect of Process Parameters on Interfacial Properties of Bilayer Tablets.
J. H. Finke1, 2, J.-L. Wichmann1, 2, Arno Kwade1, 2
1Institute for Particle Technology; TU Braunschweig; 2Center of Pharmaceutical Engineering; TU Braunschweig
10:05 COFFEE BREAK
SESSION VII: Liquid Preparations
10:30 INVITED LECTURE Design and Processing of Solid Dispersions in Pharmaceutical Industry.
C. Timpe, F. Hoffmann-La Roche, Basel
10:55Niosomal targeted drug delivery and bioimaging systems for Glioma.
D. Ag Seleci1,2, V. Maurer1,2, J. C. Porsiel1, F. Stahl3, T. Scheper3, G. Garnweitner1,2
1 Institute for Particle Technology (iPAT), TU Braunschweig; 2 Centre for Pharmaceutical Engineering Research (PVZ), TU Braunschweig; 3 Institute for Technical Chemistry, Leibniz University Hannover
11:15Electrostatic Precipitation of Submicron Particles in a Molten Carrier.
A. Justen, A. Dobrowolski, D. Pieloth, H. Wiggers, M. Thommes, TU Dortmund
11:35PGX Technology: Novel Tailor-Made and Tuneable Delivery Systems for Poorly Water-Soluble Bioactives.
B. Seifrieda, F. Temellib, D. Vineb, R. Coutob, B. Yepeza, E. Wonga, P. Moquina
a) Ceapro Inc., Edmonton; b) University of Alberta, Department of Agricultural, Food and Nutritional Sciences, Edmonton
11:55Formulation of Cannabidiol in Lipid Carriers.
N. Francke1, L. Grüne1, H. Bunjes1,2
1TU Braunschweig; Institut für Pharmazeutische Technologie; 2PVZ - Zentrum für Pharmaverfahrenstechnik; TU Braunschweig
FINAL SESSION
12:15POSTER AWARD
12:30General Discussion, Concluding Remarks. S. Scholl, Conference Chair
FAREWELL

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Abstract Submission is closed now!

Presentation formats
Applications for oral and poster presentations are invited. Oral presenta-tions will be 15 + 5 min. For posters, 3 min introductory presentations are scheduled. The posters should be printed in size A0.

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